Premyopia
Conditions
Interventions
experimental group:phase1:0.01% atropine eye drops (morning) + 0.01% atropine eye drops (evening)
frequency control group:phase1:Placebo (morning) + 0.01% atropine eye drops (evening)
Concentration control group:phase1:Placebo (morning) + 0.04% atropine eye drops (evening)
blank control group:phase1:Placebo (morning) + Placebo (evening)
Framed glasses treatment group:phase 2: for subjects in blank control group with myopia progression<-0.50D, integrated mesh defocusing lenses will be used in the second year.
Sponsors
Eye Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 6-12 years who have voluntarily participated in the premyopia (cylindrical muscle paralysis after cycloplegia spherical diopter +0.75D~-0.50D, cylindrical diopter <= 1.50D, refractive difference <= 1.50D) who have stopped the intervention for 3 months or more; 2. Children participating in the study had the consent of their guardians and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have eye diseases (e.g. cataracts, congenital retinal diseases, amblyopia, and strabismus); 2. Children with turbidity of refractive medium or surgery related to refractive media intervention, such as cataract surgery, corneal transplantation, corneal leukoplakia, keratoconus, etc.; 3. The presence of systemic diseases that may affect the refractive state, such as Marfan syndrome, Marcheshani syndrome, type 1 diabetes, etc.; 4. Those who are allergic to hyoscyamine; 5. Shallow anterior chamber, glaucoma, and family history of glaucoma; 6. Children who cannot cooperate with the examination, children who quit halfway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Equivalent spherical lens; | — |
Secondary
| Measure | Time frame |
|---|---|
| axial length; | — |
Countries
China
Contacts
Public ContactLi Xiaoman
Eye Hospital of Wenzhou Medical University
Outcome results
None listed