MDR/RR-TB
Conditions
Interventions
treatment group:chemotherapy(containing BDQ)
control group:chemotherapy(BDQ free)
Sponsors
shanghai pulmonary hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients included meet criteria following below: ? hospitalized, confirmed as MDR/RR-TB, including children, adolescent, adult; ? Pulmonary tuberculosis patients with sputum culture positive, and DST indicating at least resistant to INH and RFP and resistant to FQs, or confirmed by Xpert MTB/RIF resistant to RFP; ? The patient has no previous medication history or has a history of using second-line treatment for no more than 1 month; ? Informed consent by participants;
Exclusion criteria
Exclusion criteria: patient with the following conditions were excluded from the study: ? with DM, HIV postive, immunosuppressive agents, and immun function abnormal ?cancer, silicosis, NTM infection, severe extrapulmonary TB and EBTB; ?pregnant, infant and elders; ? allergy to the drugs in the regiments or intolerance to any drugs in the regimens; ? identification as NTM infection; ? having severe renal or liver function abnormal or chronic hepatitis, having mental illness intolerant to any drugs in the regimens; ?having heart diseases, long QTs or can not be tolerant to any drug in the regiments ? be severe and not suitable for clinical trial; ? having be in the another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| treatment success rate;culture conversation rate; | — |
Countries
China
Contacts
Public Contactfanlin
Shanghai Pulmonary Hospital
Outcome results
None listed