colorectal cancer
Conditions
Interventions
Wild-type group:None
Single heterozygous group:None
Mutant homozygous/double heterozygous group:None
Sponsors
Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Sign the informed consent; 2) Histopathological examination confirmed metastatic colorectal cancer; 3) Chemotherapy with irinotecan; 4) Age between 18-75 years old; 5) Physical condition score (ECOG) 0~2, estimated survival time =3 months; 6) Biochemical index requirements: bone marrow function (hemoglobin=10 g/dL, neutrophil count=1.5×10^9/L and platelets=100×10^9/L), renal function (serum creatinine=1.5×normal upper limit) and Liver function (serum creatinine and bilirubin < 1.5 x upper limit of normal and AST and ALT = 3 x upper limit of normal).
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy;The incidence of adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression Free Survival (PFS);Overall survival (OS);Duration of adverse reactions; | — |
Countries
China
Contacts
Public ContactXia He
Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital
Outcome results
None listed