Postoperative analgeisa
Conditions
Interventions
Intrathecal hydromorphone group:Intrathecal 150µg hydromorphone
Transversus abdominis plane block group:Ultrasound-guided abdominal transversus abdominis plane block with 60ml 0.2% ropivacaine dual four-point apporoach
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Adult patients; 2)American Society of Anesthesiologists (ASA) classification I to III; 3) Scheduled to undergo elective partial hepatectomy with general anesthesia.
Exclusion criteria
Exclusion criteria: 1)Patients whose body mass index (BMI)is equal to or less than 18kg/m2 or greater than 30kg/m2; 2)Patients with contraindications for performing intrathecal block, including coagulation dysfunction (platelets 1.5, or current anticoagulant therapy), abnormal vertebral anatomy, previous spinal disease or surgery, puncture site infection, severe chronic back pain or suspected spinal metastases of a malignant tumor ; 3)patients with ?severe comorbidities (renal dysfunction, hepatic impairment, cardiac insufficiency or severe pulmonary disease), expected to be transferred to the ICU after surgery; 4)patients with chronic pain syndrome or current opioid use exceeding 60mg of oral morphine or equivalent per day; 5) patients with allergy to drugs relevant to the study; 6)patients who can not understand the research process, the assessment; and the instructions of PCA pump; 7)patients participation in other clinical trials 3months prior to the present trial are excluded from the trail.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve(AUC) of pain score over time with movement within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the curve(AUC) of pain score over time at rest within 24 hours after surgery;Area under the curve(AUC) of pain score over time at rest and with movement after surgery ( 48 h, 72 h);Total analgetic uses within 72 h after surgery (24h,48h,72h);Time need to get out of bed after surgery;Overall satisfaction with analgesia;15-item quality of recovery scale;Length of stay in hospital after surgery; | — |
Countries
China
Contacts
Public ContactLi Qian
West China Hospital, Sichuan University
Outcome results
None listed