Skin aging
Conditions
Interventions
low dose:low dose HA
high dose:high dose HA
control:placebo control
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 120 healthy volunteers without medical diseases; 2. Women; 3. Two age groups: 18-35 (HA adequate group) and 45-65 (HA significantly decreased group). 4. Skin conditions are divided into three groups: dry, oily, neutral; 5. Loose skin or fine line/wrinkles on face/eyes (clinical score of sufficient HA group is greater than 1 point; HA decline group clinical score is greater than 3 points); 6. Dark skin (clinical score of sufficient HA group is greater than 1 point; HA decline group clinical score is greater than 3 points; 7. Dry skin (clinical score of sufficient HA group is greater than 1 point; HA decline group clinical score is greater than 3 points); 8. No skin diseases, healthy, with a certain ability to express, can truly reflect the feelings after use; 9. Subject must sign the informed consent, can follow the research protocol, use the product according to the requirements, and complete the skin test; 10. During the study, subjects do not change habits on daily diets and cosmetics throughout the study, and with no extra HA supplement..
Exclusion criteria
Exclusion criteria: 1.Subjects are allergic to the ingredients of the test product or has an uncontrolled medical condition, such as diabetes, high blood pressure, hyperthyroidism, or hypothyroidism; 2.Pregnant women or lactating women, or planning to become pregnant in the near future; 3.Subjects who have taken collagen, HA, or chondroitin sulfate as dietary supplements within 3 months; 4.Subjects who have shallow to medium chemical peels or dermabrasion and deep chemical peels within 6 weeks; 5.Subjects who have received non-ablative laser resurfacing or fractional resurfacing within 12 months; 6.Subjects who have had facial plastic surgery within 3 years, or have had Thermage therapy or other type of high-energy treatment within 12 months; 7.Subjects who have skin damage, erosion, or other injuries that may interfere this study; 8.Subjects who have received anti-wrinkle injections and facelifting within 6 months; 9.Subjects who have sunburn in one month or have enrolled in other studies within three months; 10.Subjects with severe brain, heart, liver, lung, kidney, or circulatory diseases and those with long-term drug therapy. 11.Subjects who have used anti-aging cosmetics during the study. 12.Other conditions are not suitable for participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin moisture;TEWL;skin tone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin ultrasound;Other Clinical Indicator;skin texture;skin elasticity; | — |
Countries
China
Contacts
Public ContactChao Yuan
Shanghai Skin Disease Hospital
Outcome results
None listed