Clinical study of the effect of different intravenous general anesthetic drugs (propofol, etomidate, and ciprofol) on cerebral blood flow rate during induction of anesthesia
Conditions
Interventions
Propofol group(groupP):None
Etomidate group (Group E):None
Ciprofol group (Group C):None
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 years and =65 years; 2.ASA grade I to II; 3. Patients undergoing elective surgery requiring tracheal intubation and general anesthesia; 4. Be willing to accept research and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous neurological diseases, acute intracranial lesions (intracranial infection, brain trauma, stroke, cerebral hemorrhage), cerebrovascular diseases, and inability to use transcranial Doppler; 2. Pregnant women, lactation, emergency surgery, language disorders, intellectual impairment, dementia and mental disorders; 3. Allergic history to experimental drugs (propofol, etomidate, ciprofol, ephedrine, etc.). 4. Patients with ASA grade =III; 5. Alcohol or drug abusers; 6. Patients who are receiving antihypertensive drugs, sedatives, analgesics and psychotropic drugs; 7. Morbidly obese (BMI> 40); 8. age 65 years old; 9. Patient refuses. 10. Cardiovascular diseases (hypertension, symptomatic ischemic heart disease, etc.), diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean middle cerebral artery blood flow velocity before intubation (T4) 3 min after induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure ;Total phenylephrine dosage ;Time to loss of eyelash reflex (time from start of administration to loss of eyelash reflex);Middle cerebral artery flow rate in other periods:Before induction of anesthesia (T0,pre-oxygenation, baseline value), before induction of anesthesia (T1,pre-oxygenation before medication), and 1min (T2), 2min (T3), 3min (T4), 5min (T5), 10min (T6), 15min (T7) after induction of anesthesia;Systolic cerebral blood flow velocity ;diastolic cerebral blood flow velocity;pulsatility index (PI);resistance index (RI);Total atropine consumption; | — |
Countries
China
Contacts
Public ContactChi XinJin
The Seventh Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed