Contrast-induced acute kidney injury
Conditions
Interventions
Group A/Oral hydration group/experimental group:Drink 500 mL of water within two hours before CT enhancement and 2000 mL of water within 24 hours after CT enhancement
Group B/Control group:0.9% NaCl was injected intravenously 3-4 mL/kg/h, 4 hours before and 4 hours after administration of the contrast agent
Sponsors
the First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Hospitalized patients (2) Age 18 or above (3) Informed consent and strict adherence to the research protocol (4) The range of eGFR that meets the definition of CKD3 stage is 30-60mL/min/1.73m2 (excluding 60mL/min/1.73m2), and eGFR is calculated using the CKD-EPI formula
Exclusion criteria
Exclusion criteria: (1) Allergic to iodine contrast agents; (2) pregnant or lactating persons; (3) Patients with hyperthyroid or asthma; (4) pancreatitis, intestinal obstruction, gastrointestinal dysfunction, etc. before and after the examination can not drink water; (5) Patients who cannot stop metformin 2 days before and after the examination due to the need of disease; (6) accompanied by serious systemic diseases, such as severe heart failure (LVEF < 35% or NYHA grade IV), acute heart failure, kidney failure, etc.; (7) Patients who have taken any nephrotoxic drugs such as aminoglycoside, vancomycin, cephalosporin or aspirin within 48 hours or several hours before the examination; (8) Serum creatinine value (sCr) was measured in the week before intravenous administration of iodine contrast agent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CI-AKI 48 to 72 hours after administration of contrast agent; | — |
Secondary
| Measure | Time frame |
|---|---|
| The mean relative increase in serum creatinine levels from baseline 2 to 3 days after administration of the contrast agent;adverse event; | — |
Countries
China
Contacts
Public ContactLuo Chunliu
the First Affiliated Hospital of Jinan University
Outcome results
None listed