Standford type B aortic dissection
Conditions
Interventions
Control group/Propofol group :Propofol was used for sedation during periextubation
Experimental group/Remimazolam group :Remimazolam tosilate was used for sedation during periextubation
Sponsors
Department of Anesthesia and Perioperative Medicine, Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The patient was diagnosed with Stanford type B dissection by imaging examination and the surgical type was single cardiac interventional surgery; (2) Aged 18-75, both sexes; (3) No history of alcohol addiction, or no history of alcohol consumption in the past two weeks; (4) New York College of Cardiology (NYHA) Cardiac Function Class ? or ?.
Exclusion criteria
Exclusion criteria: (1) Refuse to participate in the study; (2) Other cardiac surgery, previous cardiac surgery history, acute cardiac tamponade or myocardial infarction, severe sinus bradycardia, severe atrioventricular block or sick sinus syndrome; (3) Previous severe chronic pulmonary disease, pulse oxygen saturation <90% without oxygen inhalation; (4) Patients with Child-Pugh grade C liver function, severe liver dysfunction; (5) Patients with severe renal insufficiency requiring preoperative renal replacement therapy; (6) suffering from stroke, schizophrenia, depression, Parkinson's disease, epilepsy or dementia; (7) Unable to communicate due to language impairment or significant hearing impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure at different time points; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate at different time points;RASS score;Levels of inflammatory cytokines in blood at different time points;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactYu Chen
The First Affiliated Hospital of Nanjing Medical University(Jiangsu province Hospital)
Outcome results
None listed