Decreased ovarian reserve function
Conditions
Interventions
Experimental group:Flaxseed Oil
Control group:N/A
Sponsors
General Hospital of the Northern Theater of the People's Liberation Army Chinese People's Liberation Army
Eligibility
Sex/Gender
Female
Age
26 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1.Female Aged 40 or less who planned to IVF 2.AMH < 1.2 ng/ml 3.(AFC)< 7, 4.10 mIU/ml <FSH < 25 mIU/ml
Exclusion criteria
Exclusion criteria: 1.Female over aged 40 2.Woman with a history of ovary surgery 3.Endocrine or autoimmune disease (e.g., diabetes, thyroid disease, polycystic ovary syndrome) 4.History of antioxidant therapy in the past year ( CoQ10, panthenol, vitamin A, vitamin E, vitamin C ß - Carotene or selenium) 5.Allergy to flaxseed oil 6.In the past 3 months or currently undergoing weight loss medication or surgical treatment; In the past 3 months, in a controlled diet stage such as dieting or weight loss 7.Using drugs that affect the metabolism of macronutrients and micronutrients in the past three months, such as hypoglycemic drugs (biguanides, a- Glycosidase inhibitors, sulfonylureas, glinides, insulin, thiazolidinedione, etc.) lipid-lowering drugs (statins, beta, cholesterol absorption inhibitors, niacin, etc.). 8.Have used corticosteroids, anti-androgens, oral contraceptives, ovulation promoting drugs, and other drugs that affect hormone levels, appetite, carbohydrate absorption and metabolism in the past 3 months 9.Liver dysfunction, renal dysfunction, current or past severe cardiovascular and cerebrovascular diseases, and current severe gastrointestinal diseases that may affect nutrient absorption 10.Cancer patients or those who have received radiation and chemotherapy within five years 11. Smoking and drinking habits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MII oocyte retrieval rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| total dose of Gn;duration of stimulation;peak E2 concentration;LH concentration on the day of hCG trigger;endometrial thickness on the day of hCG trigger;duration between hCG day and oocyte collection, cancelled cycles;embryology outcomes parameters; | — |
Countries
China
Contacts
Public ContactYuyuexin
General Hospital of the Northern Theater of the People's Liberation Army Chinese People's
Outcome results
None listed