Deep muscle relaxation
Conditions
Interventions
micuronium chloride+neostigmine group (M group):None
rocuronium+sulbactam group (R group):None
Sponsors
Zhongda Hospital,Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Patients aged 18-65 years old; ? ASA (American Society of Anesthesiologists) classification I-III; ? 18.5 kg/?<BMI (Body mass index)<28 kg/?; ? No Contraindication of Laparoscopy; ? The estimated surgical time is between 1-4 hours.
Exclusion criteria
Exclusion criteria: ? Patients with severe renal dysfunction requiring dialysis or creatinine clearance rate less than 30 milliliters per minute; Patients with severe liver function impairment (Child Pugh grade C) or liver function impairment accompanied by coagulation disorders; ? Patients with epilepsy, angina pectoris, ventricular tachycardia, mechanical Bowel obstruction or urinary tract obstruction, asthma, severe arrhythmia, sinus bradycardia or Vagus nerve tension elevation; ? Neuromuscular system disease; ? Pregnant and lactating women, women with pregnancy expectations in the next 3 months; ? Patients with muscle relaxation monitoring sites that have trauma, surgical history, or infection that affect muscle relaxation detection; ? Malignant hyperthermia tendency; ? Suspected individuals with abnormal plasma cholinesterase activity; ? Patients who have participated in other drug clinical studies within the past 30 days and have been included in this study have been re admitted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Residual rate of muscle relaxation; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP.HR.SPO2;Dosage of vasoactive drugs;Time from discontinuation of muscle relaxants to extubation and post anesthesia monitoring treatment (PACU) residence time;VAS and sedation scores during PACU; | — |
Countries
China
Contacts
Public ContactJin Wang
Department of Anesthesiology, Zhongda Hospital, Southeast University
Outcome results
None listed