Adolescent depression
Conditions
Interventions
Experimental group:8 weeks of moderate intensity aerobic exercise
Sponsors
Shanghai East Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 12 to 18, gender unlimited; 2. Meet the ICD-10 diagnostic criteria for depression, mild to moderate degree; 3. The subject does not receive any antidepressant treatment in the last one month(such as drugs, psychotherapy, or physical treatment); 4. The subject and guardian sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Comorbid the following psychiatric disorders: Anxiety disorder, organic emotional disorders, substance dependence, mental retardation, schizophrenia, bipolar affective disorder, post-traumatic stress disorder, personality disorder, etc; 2. Got the physical diseases that affect the immune system (infectious diseases; Asthma, rhinitis, and other allergic diseases; Systemic lupus erythematosus, anaphylactoid purpura, Kawasaki disease and other autoimmune diseases; Immune deficiency etc.) 3. Professional athlete, or suffers from a physical disease unfit for exercise; 4. Currently receiving anti-inflammatory medication; 5. The subjects at risk of suicide or assault,.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines(IL-1ß?IL-6?IL-8?IL-10?TNF-a);kynurenine pathway metabolite (KYN?3-HK?KA?TRP);hair cortisol;Magnetic resonance spectrum imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scales(CDI?SCARED?ASLES?CTQ?PHQ-13); | — |
Countries
China
Contacts
Public ContactChuanyuan Kang
Shanghai East Hospital Affiliated to Tongji University
Outcome results
None listed