skin problem
Conditions
Interventions
Sample group 1:Subjects were given a solid drink containing 90 mg of N-acetylneuraminic acid once a day for 60 days
Sample group 2:Subjects were given a solid drink containing 180 mg of N-acetylneuraminic acid once a day for 60 days
control group:The subjects should take the same dose of solid drink which is harmless to human body and the physical factors such as the appearance and smell of the sampleonce a day for 60 days.
Sponsors
Xiamen University
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 35-60 years; 2. Skin type requirements: loose and dry skin; 3. Wrinkle requirements: Subjects with crow's feet who have been evaluated by professionals as grade 2 or above; 4. The test site has at least one obvious stain with ITA degree difference greater than 10 degree from the surrounding skin, and the diameter is not less than 3mm (it cannot be freckles, pigmented moles, etc., which are difficult to be improved by clinical use of topical preparations); 5. No allergic disease, no history of allergy to cosmetics and other external preparations; 6. History of aphotosis disease, no recent use of drugs affecting photosensitivity; 7. The skin of the test site should be free of birthmarks, inflammation, scars, hairiness and other phenomena; 8. The subject undertakes not to change the habit of using the existing skin care products during the test; 9. Ensure that facial samples with the same function other than test samples are not used during the test; 10. During the test period, the subjects did not participate in long-term outdoor sports and did not plan to travel to the sunny place by the sea; 11. People who are not very low in makeup awareness; 12. No laser or chemical stripping has been performed; 13. All subjects were in good health with no family history of diabetes, abnormal glucose tolerance, prediabetes and other subclinical metabolic abnormalities; 14. Those who can understand the test process, voluntarily participate in the test and sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Persons with skin diseases or disease history (severe freckles, atopic skin diseases, psoriasis, eczema severe acne, etc.), who are not suitable for participating in the project according to clinical evaluation; 2. Had sunburn in the 1 month prior to enrollment, had participated in other facial clinical studies or had been treated by a dermatologist in the current or recent 3 months; 3. Use of dietary supplements containing collagen, hyaluronic acid, chondroitin sulfate, or any combination thereof in the 3 months prior to enrollment; 4. Chemical exfoliation, botox and dermal fillers were performed within 6 months before enrollment; 5. Non-stripping laser in the 12 months prior to enrollment; 6. Facial plastic surgery or exfoliative laser in the 3 years prior to enrollment; 7. Active, allergic, severe systemic disease, immune deficiency or autoimmune disease; 8. Those who have used hormone drugs and immunosuppressants in the past one month; 9. Pregnant, lactating, peers and those assessed as unsuitable by the experimenter; 10. Other clinical experimenters participated in the test site in the past three months; 11. Serious damage to liver and kidney function, endocrine diseases, mental patients and women in special periods (such as breastfeeding, pregnancy); 12. Allergic constitution and allergy to this product; 13. Taking products related to the same function for a short period of time; 14. Discontinuation of use during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stratum corneum moisture content;Transepidermal water loss rate;Skin elasticity parameter R2 value;Skin tightening parameter F4 value;Degree of wrinkle;Color class;individual type angle, ITA°;Melanin Index (MI);Color spot area ratio\color spot optical density average;GSH (reduced glutathione);SOD (superoxide dismutase); | — |
Secondary
| Measure | Time frame |
|---|---|
| Respondents' self-evaluation parameters;Before and after facial skin images were compared; | — |
Countries
China
Contacts
Public ContactHongwei Li
Xiamen University
Outcome results
None listed