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Clinical effect of allogeneic demineralized bone matrix for bone augmentation in jaw defects

Clinical effect of allogeneic demineralized bone matrix for bone augmentation in jaw defects

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073739
Enrollment
Unknown
Registered
2023-07-20
Start date
2021-07-15
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

jaw defect

Interventions

Extraction site preservation test group:Minimally invasive extraction of single anterior or posterior teeth with no preservation value under local anesthesia, removal of granulation tissue in the extr
Extraction site preservation control group:Minimally invasive extraction of single anterior or posterior teeth with no retention value under local anesthesia, with modified horizontal mattress sutures
Vertical bone augmentation case group of single anterior teeth:Preoperative analysis was performed based on the patient's CBCT, and a customized bone ring (outer diameter, inner diameter, and height)
Intramaxillary sinus lift group:After the maxillary posterior missing teeth area was incised and flapped, the implant socket was prepared, and after the maxillary sinus punch-top internal elevation, t
Maxillary sinus external elevation test group:After the lateral wall of the maxillary sinus was opened with an ultrasonic bone knife in the maxillary edentulous area, the maxillary sinus was elevated

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients who have teeth that cannot be retained and need to be extracted and then postponed for implant restoration, and the extraction site is subjected to site preservation surgery; (2) Patients with insufficient sinus ridge distance at the missing site in the posterior region who need to undergo implant restoration after maxillary sinus internal elevation or external elevation surgery, and the area of sinus floor elevation surgery needs to be filled with bone filling materials; (3) A single missing anterior tooth with vertical bone defect at the missing site requires bone augmentation surgery; (4) Patients with multiple consecutive missing teeth with large horizontal and/or vertical bone defects requiring bone augmentation surgery. (5) Age =18 years old, male or female; (6) Good oral hygiene; (7) Non-smoker or <10 cigarettes/day, non-alcoholic; (8) Good general condition and assessed to be able to tolerate the surgery; (9) Have signed the Informed Consent Form.

Exclusion criteria

Exclusion criteria: (1) Any systemic disease that may have contraindications to surgery, such as uncontrolled diabetes, hypertension, immunocompromised, coagulation disorders, radiotherapy, chemotherapy, alcohol or drug abuse, oral and/or intravenous bisphosphonates drug (2) Poor oral hygiene or inability to perform oral hygiene maintenance as prescribed by the doctor (3) Smokers > 10 cigarettes per day or heavy drinkers (4) Patients with active periodontitis do not receive basic periodontal therapy (5) Pregnant or lactating women (6) Patients who cannot tolerate implant surgery

Design outcomes

Primary

MeasureTime frame
Bone height;Bone width;

Secondary

MeasureTime frame
Complications after bone grafting;

Countries

China

Contacts

Public ContactJianping Chen

Zhejiang Provincial People's Hospital

1522643060@qq.com+86 159 0664 4221

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026