Elderly surgical patients
Conditions
Interventions
Fospropofol disodium group:fospropanol disodium 5-10mg/kg/h for anesthesia maintenance
Propofol group:Propofol 3-5 mg/kg/h
Sponsors
Hefei BOE Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Obtaining informed consent; (2) Age = 60 years and = 90 years; (3) Patients to be operated on with general anesthesia; (4) American Society of Anesthesiologists (ASA) classification I-III;
Exclusion criteria
Exclusion criteria: (1) Preoperative severe cardiac, cerebral, pulmonary, hepatic, renal and other important organ insufficiencies and electrolyte abnormalities (2) history of psychiatric illness or long-term psychotropic drugs (dementia, schizophrenia), history of chronic analgesic drugs, history of alcoholism (3) A history of poorly controlled hypertension or ischemic heart disease; (4)) Those with a history of allergy to intraoperative drug use (5)) Those with a history of peripheral arterial vascular and/or cerebrovascular disease (6) Patients with prolonged QT interval on preoperative ECG. (7) Patients with severe infections. (8) Patients with expected surgical bleeding >1000ml. (9) Patients taking anticoagulants such as aspirin or with coagulation disorders. (10) Patients with preoperative cognitive impairment as determined by the MMSE scale. (11) Pregnant or lactating women. (12) Participating in other drug trials within three months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic indexes;Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time for patients to open their eyes after awakening from anesthesia;Number of intraoperative hypotension, bradycardia, hypertension, and tachycardia requiring pharmacological intervention;Satisfaction of anesthesiologists, surgical operators and patients with anesthesia results; | — |
Countries
China
Contacts
Public ContactDengrong Wei
Hefei BOE Hospital
Outcome results
None listed