Disorders of consciousness
Conditions
Interventions
Subjects with Disorders of consciousness (Study 1):NA
Subjects with Disorders of consciousness (Study 2):NA
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Male or female patients aged 18-80 years ? The CRS-R assessment and clinical diagnosis of consciousness disorder (including vegetative state/unresponsive awakening syndrome, microconscious state, detachment from microconscious state, silence, etc.) ? =28 days from the onset of disturbance of consciousness ? There are clear causes of consciousness disorders, including brain trauma, cerebral hemorrhage, cerebral infarction, ischemic hypoxic encephalopathy, etc ? The legal guardian agrees and signs the "informed consent" No major chronic diseases, malignant tumors or acute infectious diseases have been confirmed by the researchers ? Stable vital signs, no obvious contraindications.
Exclusion criteria
Exclusion criteria: ? 80 years old ? Acute stage of disturbance of consciousness (onset < 28 days) ? Suffering from severe gastrointestinal, cardiovascular, liver, kidney, blood system, endocrine system, respiratory system disease, immune deficiency, tumor or other serious diseases Candidate subjects have undergone major surgery within the last 3 months; Received an experimental drug or device within 1 month (with unclear efficacy or safety).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CSR-R;Thyroid function;Sex hormone;neuron-specific-enolase;Heart rate variability;PRL; | — |
Secondary
| Measure | Time frame |
|---|---|
| pet-ct suv;Event-Related PotentialS;Oxygenate hemoglobin;Deoxygenate hemoglobin, HbR;Blood routine;DDI; | — |
Countries
China
Contacts
Public ContactWu Yi
Huashan Hospital, Fudan University
Outcome results
None listed