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Comparison of the effect of Bupivacaine liposome and Ropivacaine combined with dexmedetomidine intramuscular sulcus brachial plexus block for upper limb fracture surgery on postoperative analgesia: a randomized clinical trial

Comparison of the effect of Bupivacaine liposome and Ropivacaine combined with dexmedetomidine intramuscular sulcus brachial plexus block for upper limb fracture surgery on postoperative analgesia: a randomized clinical trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073700
Enrollment
Unknown
Registered
2023-07-19
Start date
2023-07-20
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

humeral fracture

Interventions

Group A:Bupivacaine liposomes were 133mg / 10ml 66mg bupivacaine and diluted to 20ml using normal saline
Group B: 100mg/10ml Ropivacaine combined with 1µg/kg dexmedetomidine and diluted to 20ml using normal saline

Sponsors

Affiliated Shunde Hospital of Jinan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 years, AA I to III, patient undergoing upper limb fracture surgery

Exclusion criteria

Exclusion criteria: Patients who refuse to participate or who are not suitable to participate in the trial; There were contraindications to anesthesia and surgery. Patients with a history of neuropathy; Cervical spondylosis (i.e. disc herniation, myelopathy); People with neurological conditions (such as myelopathy) or other neurological conditions; Chronic pain; Patients allergic to related drugs; Severe cardiovascular and respiratory allergy; People with mental illness or cognitive impairment; Long-term use of opioids or other analgesics; Pregnant patients.

Design outcomes

Primary

MeasureTime frame
Consumption of opioid analgesics within 72 hours of surgery (converted to oral morphine);

Secondary

MeasureTime frame
Recovery quality within the PACU;Pain scores at 6,12,24,48,72 (at rest and exercise);Block-related adverse events;Duration of the motor and sensory blocks;Number of analgesic pump presses;

Countries

China

Contacts

Public Contactzhang zhongqi

Affiliated Shunde Hospital of Jinan University

jxzzq11@139.com+86 137 9868 2324

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026