Intraoperative hypotension
Conditions
Interventions
Propofol group:Propofol
Remimazolam combined with esketamine group:Remimazolam combined with esketamine
Remimazolam group:Remimazolam
Propofol combined with esketamine group:Propofol combined with esketamine
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 18 < age =65 years old, regardless of gender; 2. Planned laparoscopic (tracheal intubation) surgery, the expected duration of anesthesia was 1-3 hours; 3. ASA grade ? or ?; 4. 18 kg/m2 < BMI < 30 kg/m2; 5. Understand and voluntarily participate in the study, and sign the informed consent form by themselves.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; Hypovolemia, shock or coma; 2. In addition to general intravenous anesthesia, other anesthesia methods should be combined, such as inhalation, epidural, subarachnoid anesthesia, etc. 3. Infectious heart diseases such as myocarditis or endocarditis, septicemia; 4. Cardiopulmonary bypass was planned; Heart, liver and kidney transplants were planned. The type of planned operation may affect the collection of BIS index. 5. Patients with large estimated intraoperative blood loss; 6. Abnormal coagulation function; 7. Anemia or thrombocytopenia; 8. Abnormal liver and kidney function; 9. Complicated with acute heart failure, unstable angina and other cardiovascular diseases; 10. Patients with hypertension and hypotension whose blood pressure is not adequately controlled; 11. Patients with a history of craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, cerebrovascular accident, or central nervous system disease; 12. Diabetic patients with inadequate glycemic control; 13. A history of drug abuse and/or alcohol abuse within 2 years before screening; 14. Patients with mental disorders, long-term use of psychotropic drugs and cognitive impairment; 15. Pregnant or lactating women; 16. Allergic or contraindicated to benzodiazepines, opioids, propofol, esketamine, muscle blockers and other drugs and their components; 17. Patients judged to have airway management difficulties; 18. Any other circumstances that the investigator considered inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| The success rate of anesthesia;Anesthesia induction time;Anesthesia recovery time;Time to leave PACU;Dosage of sedatives;Dose of opioids;Dosage of vasoactive agents;Intraoperative blood loss;Agitation score after extubation and extubation;VAS pain score after extubation;Orientation score and orientation recovery time after extubation;Satisfaction with anesthesia;The scores of QoR-15 scale on d1, d3 and d30 after surgery;Time-weighted mean of intraoperative hypotension;The number of hypotensive events per patient;The total time of intraoperative hypotension;The percentage of time hypotension occurred;Adverse event;BIS changes; | — |
Countries
China
Contacts
Public ContactMiao Changhong
Zhongshan Hospital, Fudan University
Outcome results
None listed