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Comparison of the effects of sacubitril/valsartan and azilsartan on left ventricular remodeling in hypertensive patients with elevated angiopoietin-like 7 based on two-dimensional speckle-tracking echocardiography

Comparison of the effects of sacubitril/valsartan and azilsartan on left ventricular remodeling in hypertensive patients with elevated angiopoietin-like 7 based on two-dimensional speckle-tracking echocardiography

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073598
Enrollment
Unknown
Registered
2023-07-15
Start date
2023-07-15
Completion date
Unknown
Last updated
2023-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension

Interventions

SV group:Shakubaqu valsartan 200mg/dose, once daily
AZL group:Azilsartan 20mg/dose, once daily

Sponsors

The First People's Hospital of Lianyungang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) aged 18-80 years; (2) Clear diagnosis of hypertension (in accordance with the diagnostic criteria of the 2021 Revised Chinese Guidelines for the Prevention and Treatment of Hypertension): systolic blood pressure = 140mmHg and/or diastolic blood pressure = 90mmHg; (3) The initial onset of hypertension is not treated or the treatment control is not up to standard; (4) Echocardiography screening results Simpson (biplane method) measurement of left ventricular ejection fraction (LVEF)>50%; (5) Sinus rhythm; (6) Sign informed consent form

Exclusion criteria

Exclusion criteria: (1) Secondary or stubborn hypertension; (2) Various types of cardiomyopathy; (3) Heart valve disease; (4) Clarify coronary heart disease; (5) Pericardium disease; (6) Severe liver, kidney, and lung dysfunction; (7) Individuals with mental illness or severe mental symptoms; (8) Pregnant and lactating women; (9) Suspected or confirmed history of alcohol or drug abuse

Design outcomes

Primary

MeasureTime frame
systolic pressure;diastolic pressure;

Secondary

MeasureTime frame
renal function;Angiopoietin like protein-7;

Countries

China

Contacts

Public ContactLi Gonghao

The First People's Hospital of Lianyungang

lgh0805@126.com+86 189 6132 7781

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026