children's interstitial lung disease
Conditions
Interventions
Gold Standard: Children younger than 2 years old: 1. Respiratory symptoms, such as cough, shortness of breath, and activity intolerance. 2. Physical sign, such as shortness of breath at rest, rales
Index test:Transbronchial cryobiopsy
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: (1) Age = 18 years old, male or female; (2) Those who are suspected as chILD according to the diagnostic criteria for chILD; (3) Low-flowing oxygen intake arterial oxygen partial pressure > 60mmHg; (4) High-resolution CT of the chest shows unexplained diffuse lesions of both lungs, and the main lesions are located in the distal bronchial lung tissue or peripheral lung lesions below the bronchi of both lung segments; (5) The diagnosis cannot be confirmed by laboratory examinations, imaging examinations or routine bronchoscopy; (6) Cardiopulmonary function can tolerate general anesthesia, coagulation function is normal; (7) Voluntarily participate and the child's legal guardian signs the informed consent form. The process of obtaining informed consent complies with GCP regulations.
Exclusion criteria
Exclusion criteria: (1) Those who have contraindications to pediatric bronchoscopy and cannot be corrected; (2) Those who have poor compliance and cannot complete this study; (3) Those who are participating in clinical trials or have participated in other clinical trials in the past three months; (4) Those who are not suitable to participate considered by investigators in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical manifestations and concomitant diseases;radiological data;Bronchoscopy and transbronchial biopsy;Indicators for bronchoalveolar lavage fluid;Size and quality of specimens;Diagnostic performance of specimens;Efficiency of pathological diagnosis;Incidence and severity of complications;Accuracy of pathological diagnosis ;Specificity of pathological diagnosis ;Sensitivity of pathological diagnosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic information;Current and past medical history;History of growth and development;Family health history;Clinical treatment and therapeutic effect;Lab test results;Pulmonary function tests;Surgical procedures;Genetic screening; | — |
Countries
China
Contacts
Public ContactLeping Ye
Peking University First Hospital
Outcome results
None listed