None
Conditions
Interventions
CCFM8610 intervention group:During the trial, baseline is to be collected and probiotic CCFM8610 (10^9 CFU) is to be ingested for one day only, with one stool per day on the day of the intervention an
Placebo group:During the trial, baseline needs to be collected, placebo (maltodextrin) is ingested for one day only and stools are taken once a day on the day of the intervention and 7 days after the
Sponsors
School of Food Science and Technology, Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Healthy men and women aged 18 to 70 years, with a male to female ratio of 1:1; (2) Not currently following any dietary programme or dietitian consultation; (3) BMI: 18.5 to 24.9 kg/m2; (4) Compliance with relevant regulations during the clinical trial, good adherence and ability to deliver samples on time; (5) The volunteer or guardian has signed the informed consent form; (6) Volunteers commit to cooperate with the study throughout the experimental period.
Exclusion criteria
Exclusion criteria: (1) Suffering from gastrointestinal, neurological, cardiovascular, endocrine, renal or other chronic diseases that may affect the dynamics of the bowel; (2) Having undergone major abdominal surgery, especially of the gastrointestinal tract; (3) Use of medication related to gastrointestinal conditions such as anti-spasmodics, laxatives, anti-diarrhoeal drugs and other drugs that have an effect on intestinal motility within two weeks; (4) Women during pregnancy or lactation; (5) Allergy or lactose intolerance to the ingredients of the experimental probiotic product; (6) Consumption of yoghurt, probiotics, prebiotics, synbiotics, dietary supplements, or herbal medicines within 1 month or for a prolonged period of time, herbal remedies, or taking high doses of vitamins or minerals; (7) Use of antibiotics within 1 month or for a prolonged period, glucocorticoids, immunosuppressive drugs within 3 months or for a prolonged period (8) Significant change in dietary habits within 1 month, such as starting a fibre-rich diet (>18 g/day) (9) Hospital diagnosis of chronic illness, immune system disorders, mental illness, infectious diseases or major diseases; (10) Alcohol or substance abuse; (11) Currently or recently (within 1 month) undergoing another clinical study; (12) Refusal to sign an informed consent form or poor estimated compliance and poor likelihood of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| metabolome; | — |
Countries
China
Contacts
Public ContactZhai Qixiao
School of Food Science and Technology, Jiangnan University
Outcome results
None listed