regional anesthesia
Conditions
Interventions
Medial inferior genicular nerve, 5ml 0.5% ropivacaine each). IPACK block (0.5% ropivacaine 20ml).
Ropivacaine group :Ropivacaine group: genicular nerves of knee joint (medial superior knee nerve
lateralis superior genicular nerve
Esketamine group:Esketamine group: genicular nerves of knee joint (medial superior knee nerve
Medial inferior genicular nerve, 0.5% ropivacaine 5ml+5mg esketamine in each place). IPACK block (0.5% ropivacaine 20ml+20mg esketamine).
control group:No nerve block operation
Sponsors
the First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients aged 18-90 years; ASA grades 1-3; BMI 18-40 kg/m2; A unilateral total knee arthroplasty under spinal anesthesia was planned.
Exclusion criteria
Exclusion criteria: Peripheral nerve block or contraindication to spinal anesthesia (local or systemic infection; Coagulation dysfunction; Pre-existing neurological defects or neuropathy); History of knee trauma or surgery; Any mental or mental illness that interferes with the assessment; Allergic to any component of analgesic regimens or local anaesthesia; Or chronic opioid use (=4 weeks before surgery, daily morphine equivalent dose =30mg); People with poorly controlled or untreated hypertension; Patients with untreated or undertreated hyperthyroidism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphine consumption within 24 hours after arriving at PACU;Time required for opioid analgesics;Time to meet discharge physical therapy standards;hospital stay;Recovery Quality;Rehabilitation situation;Walking distance; | — |
Countries
China
Contacts
Public ContactQuanguang Wang
the First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed