hypertension
Conditions
Interventions
the group of Kefir :Standard antihypertensive therapy + Kefir 2g po bid
Goat milk group:Standard antihypertensive treatment + oat milk powder 2g po bid
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age 18-75 years old, no limit on gender; 2. meet the diagnostic criteria for mild to moderate hypertension in the Chinese Health Management Code for Hypertension (2019); 3. 3 oral antihypertensive medications are taken, do not adjust antihypertensive medications within 2 weeks before enrollment and had stable blood pressure. 4. could communicate well with medical staff, voluntarily participated and sign the informed consent form. Those who meet all of the above are included in this study.
Exclusion criteria
Exclusion criteria: 1. patients with clearly proven secondary hypertension; 2. heart failure occurring within 3 months; 3. ACS occurring within 3 months or expected PCI or CABG; 4. ischemic/hemorrhagic stroke occurring within 3 months; 5. diabetes mellitus not well controlled (fasting glucose >11.1 mmol/L); 6. malignancy or other disease affecting 5-year survival; 7. abnormal liver function 8. renal impairment with blood creatinine >133mmol/L; 9. gastric ulcer 10. patients with severe chronic obstructive pulmonary disease; bronchial asthma not well controlled; 11. severe arrhythmias affecting hemodynamics; 12. active rheumatic immune diseases; 13. various acute and chronic infectious diseases and acute metabolic disorders 14. pregnant or lactating women or those with pregnancy plans; 15. those with stressful conditions such as surgery or severe trauma; 16. those with severe allergies, known or likely to be allergic to Corexit or its constituents; 17. those with psychiatric disorders, drug or other substance abuse. If any of the above is met, it is excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulse-wave velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinic blood pressure;ceramide;glycosylated hemoglobin;blood fat; | — |
Countries
China
Contacts
Public ContactZhao Shaohua
Qilu Hospital of Shandong University
Outcome results
None listed