Effect of nalbuphine combined with ropivacaine transversal plane block on postoperative and recovery quality in patients with laparoscopic total hysterectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300073472

Enrollment

Unknown

Registered

2023-07-12

Start date

2023-07-12

Completion date

Unknown

Last updated

2023-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia and recovery quality

Interventions

NR:Bilateral TAP block (20mg Nalbuphine+0.33% Ropivacaine) 60ml mixed solution+2ml of intravenous saline

N:Bilateral TAP block : 0.33% Ropivacaine 60ml+intravenous Nalbuphine 2ml (20mg)

R:Bilateral TAP block 0.33% Ropivacaine 60ml+intravenous injection of normal saline 2ml

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Selective laparoscopic total hysterectomy 2. Age 18-65 3. BMI 18-30 kg/m ² 4. ASA Level I - III 5. After fully explaining the clinical trial content, voluntarily joining and signing informed consent

Exclusion criteria

Exclusion criteria: 1. Mental or Nervous system disease 2. Allergies to local anesthetics 3. Preoperative Chronic pain 4. Use analgesics or receive psychotherapeutics 5. Puncture site, nearby Skin infection or systemic infection 6. Coagulation dysfunction 7. Severe heart, respiratory, kidney or liver diseases, etc 8. Serious alcoholism (average daily drinking>2 units of alcohol, 1 unit of alcohol=360 ml of beer with 5% alcohol or 45 ml of Baijiu with 40% alcohol or 150 ml of wine)

Design outcomes

Primary

Measure	Time frame
VAS pain score and visceral pain VAS score at rest and activity at 1, 2, 6, 12, 24, and 48 hours after surgery;Postoperative recovery quality score at 24 and 48 hours;	—

Secondary

Measure	Time frame
The first PCA time and the number of analgesic pump presses within 48 hours after surgery;Accumulated consumption of postoperative analgesics and frequency of remedial analgesia;Duration of nerve block;RAMSAY score for sedation at 1, 2, 6, 12, 24, and 48 hours after surgery;Mean arterial pressure and heart rate at each time point during operation;PACU stay time, first time out of bed, first time exhaust, and postoperative hospitalization time;Postoperative complications such as dizziness, nausea, vomiting, respiratory depression, and skin itching;	—

Measure

Time frame

The first PCA time and the number of analgesic pump presses within 48 hours after surgery;Accumulated consumption of postoperative analgesics and frequency of remedial analgesia;Duration of nerve block;RAMSAY score for sedation at 1, 2, 6, 12, 24, and 48 hours after surgery;Mean arterial pressure and heart rate at each time point during operation;PACU stay time, first time out of bed, first time exhaust, and postoperative hospitalization time;Postoperative complications such as dizziness, nausea, vomiting, respiratory depression, and skin itching;

—

Countries

China

Contacts

Public ContactQi Chen

The Second Affiliated Hospital of Anhui Medical University

cq_911@126.com+86 138 6610 3453

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026