Stroke
Conditions
Interventions
sham stimulation group (middle-aged adults):The sham stimulation group had two anode electrodes placed in the left M1 and PFC areas, and two cathode electrodes placed in the opposite frame area. A cur
Single target group (middle-aged adults):The placement of four electrode sizes, current intensity, frequency waveform, etc. in the single target stimulation group were consistent with those in the sha
doublei-target group (middle-aged adults):The electrode size, placement of two pairs of positive and negative electrodes, current intensity, frequency waveform, etc. of the dual target stimulation gro
Multi-target group (middle-aged adults):The four anode electrodes of the multi-target stimulation group are placed in the M1 and PFC regions, and two additional anodes are placed in the S1 and CB regi
sham stimulation group(stroke):The sham stimulation group had two anode electrodes placed in the left M1 and PFC areas, and two cathode electrodes placed in the opposite frame area. A current was only
Sponsors
Shanghai Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Research content 1- Healthy middle-aged and elderly population: 1. Aged 40-75 years, right-handed, physically and mentally healthy, with normal vision or corrected vision; 2. Mini Mental State Examination (MMSE) score > 23; 3. Cooperate with the research and voluntarily sign an informed consent form. Research Content 2- Stroke Patients: 1. Aged 40-75 years, right-handed, with normal or corrected vision; 2. Meets the diagnostic criteria for stroke, first onset, lesion involving one hemisphere, onset within 48 hours of admission and course within 6 months; 3. Clear consciousness, stable vital signs, stable condition, and no mental disorders; 4. Cooperate with the research and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Healthy middle-aged and elderly population/stroke patients: 1. Unable to sign or understand the consent form; 2. tACS contraindications: Use of implantable electronic devices, metal implants in the skull, heart, and blood vessels, local skin damage or inflammation in the stimulation area, or hyperalgesia; 3. Drug therapy for any neurological disorder or epilepsy; 4. Currently participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequence Reaction Time Task;motor evoked potential, MEP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-Interval Intracortical Inhibition, SICI;gray matter density (magnetic resonance imaging);Fugl Meyer Scale for Physical Function;Daily Living Ability Scale (Barthel Index);Balance Scale (Berg);Montreal Cognitive Assessment Scale (MoCA);Power spectral density (EEG); | — |
Countries
China
Contacts
Public ContactYu Xiaoming
Shanghai Seventh People's Hospital
Outcome results
None listed