Hepatitis B, cirrhosis, hepatocellular carcinoma
Conditions
Interventions
Gold Standard:Patients with chronic hepatitis B: positive blood for hepatitis B virus surface antigen or HBV-DNA =10^5copies/mL
Patients with hepatitis B cirrhosis: positive blood for HBV surface anti
Index test:Serum lipid profile, serum peptide profile (using high-throughput mass spectrometry)
Sponsors
Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Healthy group Inclusion Criteria: No evidence of viral hepatitis and cirrhosis of chronic liver disease. That is, adults aged 18-80 years without hepatitis virus infection on immunization tests, no images of chronic liver disease and cirrhosis on imaging tests, and no tumors in other sites, and no other metabolic diseases. 2. chronic hepatitis B group Inclusion Criteria: There is evidence of hepatitis B virus infection, but no chronic liver disease cirrhosis. That is, adults aged 18 to 80 years with immunization showing hepatitis virus infection and imaging without images of chronic liver disease and cirrhosis without tumors elsewhere and other metabolic disorders. 3. Hepatitis B cirrhosis group Inclusion Criteria: Adults aged 18 to 80 years diagnosed with chronic hepatitis B virus cirrhosis but without primary hepatocellular carcinoma, no tumors at other sites, and no other metabolic disease. 4. Hepatitis B cirrhosis liver cancer group Inclusion Criteria: Adults aged 18 to 80 years diagnosed with chronic hepatitis B virus cirrhosis complicated by primary hepatocellular carcinoma and no tumors elsewhere and no other metabolic diseases. 5. Hepatitis B cancer group Inclusion Criteria: Adults aged 18 to 80 years diagnosed with chronic hepatitis B virus infection complicated by primary hepatocellular carcinoma, but not accompanied by cirrhosis and no tumors of other sites, and no other metabolic diseases.
Exclusion criteria
Exclusion criteria: 1. Health group Exclusion criteria: patients with hypertension, diabetes, tumors and other chronic diseases, patients with a history of hepatitis B, hepatitis C and other liver diseases, age inappropriate, etc. 2, chronic hepatitis B group Exclusion criteria: patients with hypertension, diabetes, tumors and other chronic diseases, patients with a history of other liver diseases such as hepatitis C, age inappropriate, etc. 3. Hepatitis B cirrhosis group Exclusion criteria: patients with hypertension, diabetes, tumors and other chronic diseases, patients with a history of other liver diseases such as hepatitis C, age inappropriate, etc. 4. Hepatitis B cirrhosis liver cancer group Exclusion criteria: patients with hypertension, diabetes, tumors and other chronic diseases, patients with a history of other liver diseases such as hepatitis C, age inappropriate, etc. 5. Hepatitis B cancer group Exclusion criteria: patients with hypertension, diabetes, tumors and other chronic diseases, patients with a history of other liver diseases such as hepatitis C, age inappropriate, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum lipid profile;Serum peptides profile; | — |
Countries
China
Contacts
Public ContactLiang Xiao
Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed