None
Conditions
Interventions
Oligofructose intervention in the high group:Oligofructose intervention for 14 days
Oligofructose intervention in the low group:Oligofructose intervention for 14 days
Inulin intervention in the high group:Inulin intervention for 14 days
Inulin intervention in the low group:Inulin intervention for 14 days
Sponsors
School of Food Science and Technology, Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Healthy men and women aged 18 to 70 years, with a male to female ratio of 1:1; (2) Not currently following any dietary programme or dietitian consultation; (3) BMI: 18.5 to 24.9 kg/m2; (4) Compliance with relevant regulations during the clinical trial, good adherence and ability to deliver samples on time; (5) The volunteer or guardian has signed the informed consent form (Schedule 1); (6) Volunteers completed the basic information questionnaire (Schedule 2), the dietary structure and living conditions questionnaire (Schedule 3), and the gastrointestinal symptoms rating scale (Schedule 4), and undertook to cooperate with the study throughout the experimental period.
Exclusion criteria
Exclusion criteria: (1) Suffering from gastrointestinal, neurological, cardiovascular, endocrine, renal or other chronic diseases that may affect the dynamics of the bowel; (2) Having undergone major abdominal surgery, especially of the gastrointestinal tract; (3) Use of medication related to gastrointestinal conditions such as anti-spasmodics, laxatives, anti-diarrhoeal drugs and other drugs that have an effect on intestinal motility within two weeks; (4) Women during pregnancy or lactation; (5) Allergy or lactose intolerance to the ingredients of the experimental probiotic product; (6) Consumption of yoghurt, probiotics, prebiotics, synbiotics, dietary supplements, herbs, or high doses of vitamins or minerals within 1 month or for a prolonged period of time; (7) Use of antibiotics within 1 month or for a long period of time, glucocorticoids, immunosuppressive drugs within 3 months or for a long period of time; (8) Significant change in dietary habits within 1 month, such as starting a fibre-rich diet (>18 g/day) (9) Hospital diagnosis of chronic illness, immune system disorders, mental illness, infectious diseases or major diseases; (10) Alcohol or substance abuse; (11) Undergoing other clinical studies within 1 month (12) Refusal to sign the informed consent form or poor estimated compliance and poor likelihood of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Gastrointestinal Symptom Rating Scale,GSRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-chain fatty acid;Fecal metabolome; | — |
Countries
China
Contacts
Public ContactQixiao Zhai
School of Food Science and Technology, Jiangnan University
Outcome results
None listed