Seasonal allergic rhinitis in children
Conditions
Interventions
Sponsors
Beijing Children's Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Have a history of seasonal allergic rhinitis (hay fever), and be included in the group before this season's pollen dissemination, that is, before the onset of symptoms; 2. The age is 4-12 years old, male and female are not limited; 3. Subjects aged 5-12 years (not including 12), and have a history of seasonal allergic rhinitis for at least two years, with or without conjunctivitis; Subjects aged 4-5 years (not including 5) have a history of seasonal allergic rhinitis for at least one year, with or without conjunctivitis (consultation); 4. Meet the diagnostic criteria of allergic rhinitis, and refer to the guidelines for the diagnosis and treatment of allergic rhinitis (2022, Revised); 5. Among the four rhinitis symptoms (itchy nose, stuffy nose, sneezing and runny nose), the score of rhinitis symptoms is >= 2 points (the symptom score of the last pollen season collected by consultation); 6. Seasonal pollen serum specific IgE level 2 or above or skin pricks ++ or above; 7. Volunteer and sign the informed consent form; 8. Patients who have not received other allergy drugs or other types of immunomodulatory drugs within 4 weeks.
Exclusion criteria
Exclusion criteria: 1. The patients with nasal polyps and obvious structural abnormalities of nasal cavity are easy to cause abnormal ventilation function after physical examination; 2. Snoring with adenoidal hypertrophy and / or tonsillar hypertrophy during the screening evaluation period (consultation); 3. Past and present patients with interstitial lung disease, muscular dystrophy, congenital immunodeficiency, malignant tumors, autoimmune diseases, airway dysplasia and other major diseases; 4. Patients with oral disease, heart disease, chronic kidney disease and gastric ulcer during the screening and evaluation period (consultation); 5. People with perennial rhinitis (consultation); 6. Screening and evaluation: in the last pollen season, rhinitis can be relieved by itself without oral antihistamines or nasal spray of hormones (consultation); 7. Previous history of asthma; 8. Systemic glucocorticoids were used systematically within four weeks before taking medicine; 9. Those who have participated in other clinical trials within three months; 10. Any other circumstances that the researcher believes are not suitable for participating in the trial. Note: the inquiry information is only judged by the inquiry results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom score;Drug score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life score;Total efficiency;Blood routine examination;Determination of cytokines in peripheral blood; | — |
Countries
China
Contacts
Public ContactGe Wentong
Beijing Children's Hospital Affiliated to Capital Medical University
Outcome results
None listed