Liver Faiure induced by Amatoxin-containing Mushrooms
Conditions
Interventions
Treatments Group A:Bile Drainage+Standard Conventional Treatments
Treatments Group B:Standard Conventional Treatments
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2.A definite history of consumption of poisonous mushrooms before the onset of the disease (morphologically confirmed to be amatoxin-containing mushrooms based on the provided mushrooms in kind or photographs, or detection amatoxin in blood or urine); 3. 6h after consuming the poisonous mushroom, digestive symptoms such as poor appetite, nausea, vomiting, abdominal distension, and progressive elevation of liver biochemical and coagulation indexes were observed. Liver function and coagulation were monitored every 8h, and the indexes met the diagnostic criteria for prehepatic failure. 4. duration of disease <= 7d; 5. Agree to participate in this study and sign a written informed consent
Exclusion criteria
Exclusion criteria: Those meeting any of the following criteria were excluded in this study: 1. Hemodynamically unstable, or critically ill with an expected survival time of <24 hours 2.Pregnant or lactating women; 3. The presence of any other condition that the investigator considers inappropriate for inclusion in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate; In-hospital mortality rate;cure rate;Duration of disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| MELD score;Serious complications related to liver injury;extubation;Bleeding;Infeiction; | — |
Countries
China
Contacts
Public ContactJiawei Geng
The First People's Hospital of Yunnan Province
Outcome results
None listed