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Effect of splenic sympathetic blockade on a7nAChR-dependent cholinergic anti-inflammatory pathway

Effect of splenic sympathetic blockade on a7nAChR-dependent cholinergic anti-inflammatory pathway

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073438
Enrollment
Unknown
Registered
2023-07-11
Start date
2023-07-15
Completion date
Unknown
Last updated
2023-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lung injury

Interventions

sympathetic blockade:sympathetic blockade
Vertical ridge muscle block:Vertical ridge muscle block

Sponsors

The First Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: ?, elective in thoracoscopic lung surgery patients, both men and women; ?, ASA?~? level; ?, Age is from 20 to 60 years old.

Exclusion criteria

Exclusion criteria: ?, patients with obvious anatomical abnormalities; ?. Significant intraoperative and postoperative complications; ?, co-infected, empyema, and severely impaired lung function in patients. ?, Patients with mental system diseases (schizophrenia, mania, bipolar abnormalities, mental disorder, etc.), and long-term history of psychiatric drugs and cognitive dysfunction; ?. History of drug abuse, drug use, and alcohol abuse in the two years before the start of the screening period. A history of alcoholism is an average daily drinking volume of more than 2 units (1 unit equals 360 ml of beer or 45% of liquor or 150 ml of wine); ?, Emergency surgery, shock and coma patients; ? Other circumstances that the investigator considers not unsuitable for the study.

Design outcomes

Primary

MeasureTime frame
IL-1;IL-6;TNF-a;a7nAChR;

Countries

China

Contacts

Public ContactQu Liangchao

The First Affiliated Hospital of Nanchang University

ferry7@163.com+86 180 7012 8651

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026