Ulerative Colitis
Conditions
Interventions
Sponsors
Hong Kong Baptist University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years. 2. Has previously diagnosed of ulcerative colitis. 3. Had colonoscopy with biopsy within 12months and full Mayo score > 3 (colonoscopy score < 3) before study entry. 4. Individuals should fully understand what is involved in this study and give documented consent to participate in the study.
Exclusion criteria
Exclusion criteria: Patients who meet one of the following criteria will be excluded: 1. Individual who unwilling to provide screening biopsy, blood or stool. 2. Individual who has been taken antibiotics or/and probiotics in the past one month. 3. Abnormal colonoscopy and biopsy pathology report, such as crypt epithelial dysplasia (intraepithelial neoplasia) or cancerous. 4. Intestinal stenosis. 5. Infectious enteritis or any suspicion of the presence of infectious enteritis (e.g., present of positive in the clostridium difficile test). 6. Laparotomy or laparoscopic surgery, surgery for hemorrhoids or perianal abscess, endoscopic mucosal resection or endoscopic intestinal dilation or endoscopic intestinal dilatation of the colon within 60 days before eligibility determination. 7. History of resection of the small intestine, cecum, colon or rectum. 8. Individuals with moderate or severe hepatic or renal disease or clinically significant bleeding disorder. 9. Individuals with any serious comorbid disease, such as hematological, respiratory, cardiovascular, or neuropsychiatric disease, or metabolic/electrolyte abnormality. 10. Individuals undergoing treatment or follow-up under 5 years for a malignant tumor. 11. History of alcohol or drug abuse. 12. Pregnant and nursing women and women suspected of being pregnant. 13. Individuals who are participating in any other clinical researches at study entry. 14. Others whom the investigator or co-investigator considered inappropriate for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tissue biopsy transcriptomes ;serum inflammatory cytokines profiles;Longitudinal variance in gut microbial over a year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Full Mayo score;Partial Mayo score;IBD questionnaire (IBDQ); | — |
Countries
China
Contacts
Public ContactBian Zhaoxiang
Room 307, Jockey Club School of Chinese Medicine Building, 7 Baptist University Road, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China
Outcome results
None listed