Post-stroke cognitive impairment
Conditions
Interventions
Control group:rTMS (magnetic stimulation frequency 10HZ, magnetic stimulation intensity 80%RMT, every 5 seconds, the interval is 25 seconds, and each treatment is 20min minutes. )
Experimental group:(intermittent TBS, iTBS) (The stimulation intensity was 56%RMT, and the basic stimulation frequency was 50 Hz. One short array stimulation was given every 200ms, and there were thr
Sponsors
Zhengzhou Central Hospital affiliated to Zhengzhou University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows:1. Aged 30 and 75 years;2. Right-handed;3.Patients who meet the diagnostic criteria for vascular cognitive impairment in the '' Expert consensus on Research on prevention and treatment of Poststroke Cognitive Impairment in China'' and ''Chinese Guidelines for Vascular Cognitive Impairment 2019'' are mainly summarized as follows:(1) At least one cognitive impairment (MoCA<=24) confirmed by clinical and neuropsychological assessment, and the presence or absence of activities of daily living impairments (IADLs);(2) Imaging evidence of stroke confirmed by magnetic resonance imaging (MRI) or Head CT;(3) Cognitive impairment should be independent of motor/sensory sequelae of vascular events, and there should be a clear temporal relationship between vascular events and the onset of cognitive impairment (within 6 months and for at least 3 months);4. No severe aphasia and able to complete the cognitive test;5. stable vital signs, no progression of neurological symptoms; 6. Normal cognitive function before stroke;7. able of tolerating MRI scan;8.Patients and (or) family members have informed consent, and sign the informed consent.
Exclusion criteria
Exclusion criteria: The exclusion criteria were as follows: 1.complete left prefrontal cortex injury confirmed by CT/MRI; 2. Drug/alcohol abuse/dependence within the last 3 months after initial detection of injury;3. cognitive function decline before stroke;4. Contraindications to rTMS treatment, such as epilepsy patients, brain tumor, brain trauma; pregnant or breastfeeding women, or the use of metal or electrical implantable devices (eg deep brain stimulators, ventriculoperitoneal shunts, aneurysm clips, pacemakers, cochlea, surgical staples on the scalp).5. MRI contraindications (such as metal implants or claustrophobia);6. Participate in pharmacological or non-pharmacological treatment research at the same time;7. Any other factors that could influence cognitive evaluation and treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Loewenstein Occupational Therapy Cognitive Assessment,LOTCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Trail Making Test A and B;fractional amplitude of frequency fluctuate, fALFF;Fugl-Meyer motor function assessment,FMA;Berg Balance Test;Hamilton Anxiety Scale,HAMA;Hamilton Depression Scale,HAMD;Barthel Index; | — |
Countries
China
Contacts
Public ContactLi Kunbin
Zhengzhou Central Hospital affiliated to Zhengzhou University
Outcome results
None listed