depression
Conditions
Interventions
placebo group:At the beginning of the experiment, during this period, the subjects took a placebo with warm water after breakfast or lunch once a day, one bag at a time
test group:At the beginning of the experiment, during this period, the subjects took probiotics with warm water after breakfast or lunch once a day, one bag at a time.
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, regardless of gender; 2. Hamilton Depression Scale (HAMD) 17 items >= 8; 3. Meets the diagnostic criteria for ROME III functional constipation; 4. Agree to consume the product to be studied during the study period; 5. Understand and voluntarily participate in this experiment, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant, lactating women or those who plan to conceive in the near future; 2. Having severe or unstable physical diseases such as heart, liver, kidney, endocrine, digestive, and blood; 3. Drug or alcohol abuse in the past year.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Constipation symptoms;Intestinal flora;Serum inflammatory factors;Serum hormone;Brain-derived neurotrophic factor;5-HT;kynurenine;tryptophan; | — |
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD;Beck Depression Inventory, BDI; | — |
Countries
China
Contacts
Public ContactJian Wang
China Agricultural University
Outcome results
None listed