breast cancer
Conditions
Interventions
Group of breast cancer (switch to AI for endocrine treatment):None
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
45 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. female, premenopausal, aged 45-55 years; pre-menopausal before treatment 2. pathological confirmed invasive breast cancer, TNM stage:T1-2N0-1M0; 3. IHC confirmed ER>50% + and FISH confirmed HER2; 4. undergoing mastectomy or breast conserving surgery, SLNB or ALND; 5. AMH<0.1ng/ml before systemic therapy 6. normal blood routine 7. normal liver and renal function; 8. ECOG 1-2; 9. breast US, MRI, CT, etc for all cases; 10. not pregnant during treatment and hCG - before treatment; 11. well cooperated and informed consented.
Exclusion criteria
Exclusion criteria: 1) distant metastasis at diagnosis; 2) receiving neoadjuvant treatment; 3) Dexamethasone allergy or other serious allergy; 4) serious cardiovascular, pulmonary, liver, renal, nervous, or psychiatry disease; 5) nerve disease NCI=1grade 6) refuse treatment, mental disease 7) pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estradiol;menstruation;anti-Mullerian hormone, AMH; | — |
Countries
China
Contacts
Public ContactChen Hongliang
Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed