parkinson disease
Conditions
Interventions
rTMS group :TMS stimulation
cTBS group:continuous theta burst stimulation
control group:sham stimulation
Sponsors
The sixth affiliated hospital of wenzhou medical university
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (3)non-motor symptoms in PD patients (with a focus on sleep symptoms). The subjects were over 18 years old. In accordance with the clinical diagnostic criteria for Parkinson's disease proposed by the International Society for Movement Disorders in 2015 [26]; Pd patients with sleep disorders, namely the first item score of the Parkinson's disease sleep scale (PDSS); Consent and informed consent were obtained from all patients before enrollment.
Exclusion criteria
Exclusion criteria: Parkinsonian syndrome (including traumatic, neoplastic, drug-induced, toxic, vascular and hydrocephalus, etc.) and Parkinsonian plus syndrome; Patients with severe anxiety and depression; Patients with a history of epilepsy; With metal implants such as cardiac pacemakers; Patients with serious diseases of other systems; Poor or inappropriate compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| deep sleep time-DST;total sleep time-TST;Unified Parkinson's Disease Rating Scale -UPDRS3;Parkinson Disease Sleep Scale-PDSS;The Insomnia Severity Index-ISI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Self-rating Anxiety Scale-SAS;The Self-rating Depression Scale -SDS; | — |
Countries
china
Contacts
Public Contacthongwei wu
The sixth affiliated hospital of wenzhou medical university
Outcome results
None listed