Postoperative cognitive dysfunction
Conditions
Interventions
Old-age group:None
Non-POD group:None
POD group:None
Sponsors
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.The inclusion criteria for young and elderly participants in the study are as follows: Age: 18-40 years; Gender and ethnicity: No restrictions; Consciousness: Clear; Participants must give their consent to participate in the study and sign the informed consent form. 2. The inclusion criteria for elderly patients undergoing elective surgery are as follows: Age: =60 years and <90 years; Gender and ethnicity: No restrictions; Surgery: Non-cardiac surgery requiring general anesthesia with scheduled/urgent abdominal or thoracic incision; Estimated surgery duration: =2 hours; Willingness to undergo postoperative patient-controlled analgesia; Participants must agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.The exclusion criteria for young and elderly participants in the study are as follows: Long-term use of psychotropic drugs; Presence of mental or psychological disorders or a family history of hereditary diseases; History of neurological disorders such as traumatic brain injury, dementia, epilepsy, stroke, Parkinson's disease, or other cognitive-related disorders; Language or visual impairments; Presence of malignant tumors, immune-related diseases, diabetes, or other metabolic disorders; Allergy to anesthesia drugs used during the perioperative period and their related components; Participation in other relevant clinical studies within the past three months; 2. The exclusion criteria for elderly patients undergoing elective surgery are as follows: Refusal to participate in the study; History of schizophrenia, epilepsy, or Parkinson's disease; Inability to complete preoperative assessment due to severe dementia, language impairments, coma, terminal illness, or other conditions; Occurrence of myocardial infarction within the previous three months; Contraindications to epidural anesthesia, including suspected spinal deformities or a history of spinal surgery, abnormal coagulation function (PT or APTT > 1.5 times the normal upper limit), platelet count 442µmol/L, with or without blood potassium >6.5 mmol/L, or clinical indication for renal replacement therapy as determined by the treating physician; Child-Pugh class C; Other conditions deemed unsuitable for participation in the study by the primary physician or investigator Allergy to medications (such as opioids) used in the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination score;Montreal Cognitive Assessment score;Plasma protein map;C3 level;APCS level;APOC3 level;HP level;LIPC level;SERPINA10 level;FGA level;FGB level;FGG level;SERPINC1 level;ITIH4 level;ITIH3 level;ORM1 level;ORM2 level;SAA1 level;SAA2 level;LGALS3BP level;C4B level;ALB level;IGFBP2 level;CST3 level;PI16 level;ENPP2 level;TCN2 level;CFD level;CPQ level;CRP level;GRN level; | — |
Countries
China
Contacts
Public ContactXinwei Huang
Shanghai Fourth People's Hospital(Shanghai Fourth People's Hospital Affiliated to Tongji University)
Outcome results
None listed