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Randomized controlled clinical study of the effects of WeiChangHao combined with quadruple therapy on Helicobacter pylori eradication rate and intestinal flora

Randomized controlled clinical study of the effects of WeiChangHao combined with quadruple therapy on Helicobacter pylori eradication rate and intestinal flora

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073347
Enrollment
Unknown
Registered
2023-07-07
Start date
2023-08-01
Completion date
Unknown
Last updated
2023-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection

Interventions

observation group:Given Rabeprazole sodium enteric-coated tablets (10mg/ time, twice/day), bismuth potassium citrate capsules (300mg/ ti(10mg/,2 /)? (300mg/,2 /),(1000mg/,2 /)+(100mg/,2 /)+(2000mg/,3
control group:Given Rabeprazole sodium enteric-coated tablets (10mg/ time, twice/day), bismuth potassium citrate capsules (300mg/ ti(10mg/,2 /)? (300mg/,2 /),(1000mg/,2 /)+(100mg/,2 /)+(2000mg/,3 /),
Healthy control group:N/A

Sponsors

The First Hospital of Nanchang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1: Age: 18~70 years old 2: 14C-urea breath test and gastric mucosa histopathology examination under gastroscopy showed positive results in any of the tests. 3: Complete clinical data.

Exclusion criteria

Exclusion criteria: 1: Previous helicobacter pylori eradication therapy 2: In the period of pregnancy or lactation 3: Mental illness, severe respiratory disease, liver and kidney disease, malignancy and other underlying diseases that may interfere with the study were present before admission 4: Previous history of gastric and duodenal surgery 5: Have used PPI preparations, antibiotics or other antibacterial drugs within 1 month in the past 6: People who are allergic to any of the drugs or drug components used in this treatment.

Design outcomes

Primary

MeasureTime frame
HP eradication rate;evaluation of improement effect of HP-related clinical symptoms;Detection of intestinal flora and its metabolites;

Secondary

MeasureTime frame
Occurrence of adverse reactions;

Countries

China

Contacts

Public ContactNian Fan

The First Hospital of Nanchang

fnian3893@126.com+86 139 7005 3893

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026