Hematological diseases
Conditions
Interventions
experimental group (anti-infection regimen based on Colistin Sulfate):None
Sponsors
The First Affiliated Hospital of Zhejiang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age = 18 years old 2) Diagnosed as hematological diseases with granulocyte deficiency and fever (single measurement of oral temperature = 38.3 ? (axillary temperature = 38.0 ?) or = 38.0 ? (axillary temperature = 37.7 ?) for more than 1 hour) 3) Combined with one of the following factors: (1)CRO positive with stool or throat swab screening; (2) Previous CRO infection; (3) The treatment of broad-spectrum anti-bacterial drugs is ineffective; (4) Hemodynamic instability 4) Good liver and kidney function: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) and total bilirubin are less than 2 times of the normal upper limit; Serum creatinine50ml/min/1.73m2 5) Sign informed consent
Exclusion criteria
Exclusion criteria: 1) Combined with other malignant tumors 2) Fever is considered to be caused by non-infectious factors 3) Pregnant or lactating women 4) Patients participating in other clinical trials at the same time 5) Other researchers think it is not suitable to be enrolled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of treatment;Rate of adverse effect; | — |
Countries
China
Contacts
Public ContactHongyan Tong
The First Affiliated Hospital of Zhejiang University
Outcome results
None listed