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Multi-modality magnetic resOnance eValuating the effect of enhanced physical Exercise on the growth rate, flow hemodynamics, vessel wall, and ventricular-aortic coupling of patients with small abdominal aortic aneurysms (AAA MOVE trial): a randomized controlled trial

Multi-modality magnetic resOnance eValuating the effect of enhanced physical Exercise on the growth rate, flow hemodynamics, vessel wall, and ventricular-aortic coupling of patients with small abdominal aortic aneurysms (AAA MOVE trial): a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073334
Enrollment
Unknown
Registered
2023-07-07
Start date
2023-07-10
Completion date
Unknown
Last updated
2023-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

abdominal aortic aneurysm

Interventions

Intervention:enhanced physical exercise program
Control:Standard clinical care

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with AAA in the outpatient or inpatient clinics will be assessed for inclusion eligibility if they meet all of the following criteria: 1) the maximum diameter of the AAA less than 5.0 cm in women, and 5.5 cm in men, 2) no need for surgical intervention judged with the morphology and symptom, 3) willing to sign the informed consent.

Exclusion criteria

Exclusion criteria: Participants will be excluded if they meet one of the following criteria: 1) patients had contraindications for MRI scanning, e.g. pacemaker implantation, claustrophobic, etc., 2) patients had severe heart failure who cannot lie down for half an hour, 3) patients had persistent controlled arrhythmia, 4) partially or totally dependent patients who need daily care or support from others, 5) patients had severe cardiac, pulmonary, and cerebral comorbidities who cannot tolerate enhanced physical exercise; 6) patients with connective tissue diseases and infectious AAA.

Design outcomes

Primary

MeasureTime frame
change in AAA diameter at 12 months;—

Secondary

MeasureTime frame
Aortic flow hemodynamic parameters: flow volume (TFV), regurgitation fraction (RF), peak systolic velocity (PSV) ; overall WSS, circumferential WSS (cirWSS), axial WSS (axiWSS) ; Pressure drop; Qualitative description of the flow regime in AAA; Quantification of vortical and helical flow;Aneurysm sac wall parameters: vessel wall thickness, T1 value, T2 value;ventricular-aortic coupling parameters: pulse wave velocity (PWV) of whole aorta; Afterload of left ventricle assessed by the VEL of whole aorta; ventricular structure; ventricular function; myocardial strain;—

Countries

China

Contacts

Public ContactJiarong Wang

West China Hospital, Sichuan University

docyuanding@gmail.com+86 132 5826 6309

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026