Fetal and infant growth and development (intrauterine development, postnatal physique, intelligence, intestinal flora, etc.)
Conditions
Interventions
Observation group:None
Sponsors
Wuxi maternal and child health care (Gynecology and Obstetrics Hospital Affiliated to Jiangnan University)
Eligibility
Sex/Gender
All
Age
No minimum to 35 Years
Inclusion criteria
Inclusion criteria: (1) Women in the early stage of pregnancy with a natural singleton pregnancy or infants born at full term with a healthy singleton who can obtain the data of pregnancy, delivery and lactation required by the research; (2) The mother or child is in good health; (3) Permanent resident of the area and communicate with family members barrier-free; (4) Voluntarily comply with and cooperate with the questionnaire survey and follow-up sampling and follow-up requirements.
Exclusion criteria
Exclusion criteria: (1) Pregnant women > 35 years old; (2) Assisted reproduction; (3) Twins or above; (4) Number of births > 2 (including this pregnancy); (5) Abnormal scanning results of posterior cervical zona pellucida (NT ultrasonic examination); (6) The mother suffers from chronic/infectious/major diseases, or suffers from hypertension, diabetes, or postpartum depression during pregnancy; (7) The mother has received antibiotic treatment for more than 7 days during pregnancy or lactation, or the baby has received antibiotic treatment for more than 7 days after birth; (8) Long-term use of probiotics/prebiotics dietary supplements by mothers during pregnancy or lactation, or long-term use of probiotics/prebiotics dietary supplements by infants after birth; (9) The mother or infant is participating in a nutritional or pharmaceutical intervention study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composition intestinal microflora;Fecal metabolomics;Fecal immunoomics;Urine metabolomics;Breast milk flora;Breast milk nutrients;Blood metabolomics;Blood immunoomics;Infant diet;Physical health of infants;Children's bone dens; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal flora;Placental flora;Immune development level of infants;Nutrition during pregnancy;Nutrition during lactation;Children's cognitive behavior; | — |
Countries
China
Contacts
Public ContactHeng Zhang
Wuxi maternal and child health care(Gynecology and Obstetrics Hospital Affiliated to Jiangnan University)
Outcome results
None listed