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A single-center non randomized parallel controlled clinical study for comparing the efficacy of thulium laser endoscopic en bloc resection followed by internal iliac artery infusion chemotherapy and radiotherapy with radical cystectomy for T2 phase muscle invasive bladder cancer patients

A single-center non randomized parallel controlled clinical study for comparing the efficacy of thulium laser endoscopic en bloc resection followed by internal iliac artery infusion chemotherapy and radiotherapy with radical cystectomy for T2 phase muscle invasive bladder cancer patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073305
Enrollment
Unknown
Registered
2023-07-06
Start date
2023-08-01
Completion date
Unknown
Last updated
2023-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bladder cancer

Interventions

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-75 2.The patient was pathologically diagnosed as T2 muscular invasive bladder cancer; 3.Imaging examination revealed no lymph node metastasis or distant metastasis of bladder cancer; 4.Organs (heart, liver, lung, kidney) function is basically normal, PS score: 0-2; 5.Bladder capacity >=200ml. 6.Agreeing to comprehensive bladder preservation treatment and can be followed up on time after treatment;

Exclusion criteria

Exclusion criteria: 1.The history of abdominal and pelvic radiation therapy; 2.Metastatic bladder cancer or other cancer involving the bladder; 3.T2 muscular invasive bladder with carcinoma in situ; 4.T2 muscular invasive bladder with neuroendocrine carcinoma; 5.T2 muscular invasive bladder with hydronephrosis; 6.Imaging diagnosis is T2 phase, but pathological diagnosis does not match 7.Those who are allergic to iodine; 8.Pregnant women or lactation patients. 9.Those who researchers believe that it is not suitable to participate in this clinical trial

Design outcomes

Primary

MeasureTime frame
Disease-free survival in 3 years;

Secondary

MeasureTime frame
Overall survival in 5 years;Disease-specific survival in 5 years;EORTC Quality of Life Questionnaire;Mortality rate in treatment period ;Adverse event occurrence rate;

Countries

China

Contacts

Public ContactLiu Haitao

Shanghai General Hospital

doctorlht69@163.com+86 153 0165 5608

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026