hypertension
Conditions
Interventions
Prehypertension group:None
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Pre-hypertension: blood pressure ranges from 120-139/80-89 mmHg, and no antihypertensive drugs have been taken in the past month; 2. 35 years=Age=80 years; 3. Permanent residence in the place of residence for 6 months; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.History of cardiovascular disease (including history of myocardial infarction, percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG));2.History of stroke (including atherosclerotic cerebral infarction or hemorrhagic stroke, but not excluding lacunar infarction and transient ischemic attack (TIA));3.Diseases associated with secondary hypertension, including renal parenchymal or renal vascular diseases, primary aldosteronism, pheochromocytoma, hyperthyroidism, etc;4.Severe liver, kidney and other organ dysfunction (ALT = 3 times the upper limit of normal, subjects undergoing dialysis treatment, or serum creatinine>2.5 mg/dl [>221 mol/L]);5.Severe acute and chronic infection, immune system disease, hematopoietic or coagulation dysfunction;6.Other serious diseases and life expectancy<12 months;7.Pregnancy or lactation;8.Work on night shift every day;9.Participants in other clinical research trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure progression: prehypertension progression to hypertension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the function of large arteries ankle brachial index [ABI], pulse wave velocity [PWV];Composite end-point events of the first occurrence of cardio-cerebrovascular events and death;All-cause death; | — |
Countries
China
Contacts
Public ContactWeili Zhang
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Outcome results
None listed