non-small cell lung cancer
Conditions
Interventions
Sponsors
TONGJI HOSPITAL
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Subjects must be diagnosed with histologically confirmed stage IV non-small cell lung cancer and >18 years of age,who are females or males with driver mutations (-). (2) Planned for anti-PD-1/PD-L1 therapy. (3) At least one easy accessible lesion of which a biopsy can be taken within one month prior to PET scan. (4) Subjects must sign informed consent prior to inclusion in this trial.,
Exclusion criteria
Exclusion criteria: (1) Female patients during pregnancy and lactation. (2) Patients with psychiatric disease, severe hepatic and renal insufficiency. (3) Patients who refuse anti-PD-1/PD-L1 therapy. (4) Patients who are claustrophobic or unable to undergo PET/CT examination. (5) Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2 antibody, or any other antibody or drug specifically targeting T-cell costimulation or immune checkpoint pathways, except anti-CTLA4 antibody. (6) Those who, in the opinion of the investigator, are otherwise unsuitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNR;Progression free survival, PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| TBR;Overall survival, OS; | — |
Countries
China
Contacts
Public ContactZhu xiaohua
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
Outcome results
None listed