Postoperative delirium (POD)
Conditions
Interventions
Group 1:Dexmedetomidine + deep anesthesia
Group 2:Dexmedetomidine + light anesthesia
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >= 60 years old; 2) American society of Anesthesiologists (ASA) classification I to III; 3) Non-cardiac major surgery (thoracic, abdominal, urology, orthopedics, spine surgery) planned for = 1.5 hours under general anesthesia; 4) Estimated postoperative hospital stay = 2 days.
Exclusion criteria
Exclusion criteria: 1) Emergency surgery; 2) Left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats/min), second-degree or higher atrioventricular block without a pacemaker, the history of Alzheimer's disease or Parkinson's disease; 3) Mini-mental State Examination (MMSE) < 23; 4) Alcohol abuse; 5) BIS monitoring cannot be applied; 6) Refusal for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days with POD;Type of POD;Pain scores at rest;Pain scores on movement;Postoperative fentanyl consumption;Incidence of hypotension;Incidence of bradycardia;Incidence of PONV;Non-delirium complications;Postoperative days of hospital stay;Postoperative cognitive function;Mortality; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed