Helicobacter pylori infection
Conditions
Interventions
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged 18-70 years; 2. Patients failed in first-line eradication regimen recommended by Chinese guidelines; 3. > 6 months after the end of previous H. pylori eradication treatment; 4. Confirmed H. pylori infection by at least one of the following tests: urea breath test, histology exam and positive bacterial culture.
Exclusion criteria
Exclusion criteria: 1. Used antibiotics,bismuth,or acid inhibitor use, including H2 receptor antagonist, PPI or P-CAB within four weeks before inclusion; 2. Treated with a regimen containing amoxicillin and furazolidone for H. pylori eradication before; 3. Current pregnancy or breastfeeding; 4. Allergy to any of the study drugs; 5. History of gastrectomy; 6. Gastric malignancy; 7. Gastroduodenal ulcer with recent hemorrhage or signs of hemorrhage within 4 weeks; 8. Had severe comorbidities or physical or mental diseases; 9. Hepatic or renal dysfunction; 10. Patients with glucose-6-phosphate dehydrogenase (G-6PD) deficiency, ulcer disease or bronchial asthma; 11. Administration of azanavir, lipivirin. Tricyclic antidepressants, levodopa, acetaminophen, guaifenesin/dextromethorphan, monoamine oxidase inhibitors, or tramadol during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rates of Helicobacter pylori; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events;compliance; | — |
Countries
China
Contacts
Public ContactYan Tianlian
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed