Skip to content

A two-arm, randomized, controlled, multimodal neuroimaging-based study to investigate the clinical mechanisms of acupuncture in the treatment of migraine without aura

Investigating the clinical mechanism of acupuncture for migraine without aura based on multimodal neuroimaging technique

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073246
Enrollment
Unknown
Registered
2023-07-05
Start date
2022-08-15
Completion date
Unknown
Last updated
2023-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine

Interventions

Experimental Group:True Acupuncture

Sponsors

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Patients with migraine without aura diagnosed according to the ICHD-3 and with the headache located at the lateral head at the hand-foot Shaoyang meridian. 2) Age 18-65 years, right handedness. 3) history of migraine for at least 1 year. 4) migraine attacks at least 2 times per month. 5) No acupuncture or medication within 24 hours of an acute migraine attack, and no preventive treatment for migraine within the past 3 months. 6) Subjects signed an informed consent form and volunteered to participate in the trial.

Exclusion criteria

Exclusion criteria: 1) other primary headaches such as chronic migraine, tension headache, neurogenic headache and cluster headache. 2) Headaches caused by other secondary headaches or other neurological disorders such as otorhinolaryngology or intracranial pathologies such as depression or Parkinson's. 3) more serious systemic diseases (cardiovascular disease, acute infectious disease, hematologic disease, endocrine disease, allergy or hemoptysis). 4) Those who have used prophylactic medication or acupuncture treatment within the last 3 months 5) Pregnancy, breastfeeding and preparation for pregnancy. 6) smokers, alcoholics and drug users 7) Those who have experienced pain within 3 days prior to the scan 8) Those with contraindications to acupuncture, such as blood disorders, local infections, etc. 9) Contraindications to MRI scanning, such as metal implants in the body, claustrophobia, etc.

Design outcomes

Primary

MeasureTime frame
Brain gray matter, white matter fibers and functional connectivity;Visual analogue scale;

Secondary

MeasureTime frame
Number of days and number of migraine attacks;Migraine-Specific Quality of Life Questionnaire;HeadacheImpactTest-6;Self-rated anxiety scale;Self-Rated Depression Scale;Hospital Anxiety-Depression Scale;

Countries

China

Contacts

Public ContactJun Wang

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

wangjunee@yeah.net+86 158 1148 0301

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026