Autism Spectrum Disorder
Conditions
Interventions
ASD group (the participant children diagnosed with ASD at baseline or follow-up):The exploratory intervention experiment is the fourth part of the project. Based on the research results of the first p
High-risk ASD group (below the DSM-5 diagnostic threshold for ASD at baseline AND follow-up) :None
Control group:None
Sponsors
Shenzhen Children's Hostipal
Eligibility
Sex/Gender
All
Age
1.5 Years to 3 Years
Inclusion criteria
Inclusion criteria: High-risk ASD group inclusion criteria: 1) Positive family history: grandparents, father, mother or sibling was diagnosed ASD; 2) Exhibit the core symptoms of the DSM-5 diagnostic criteria for ASD (i.e., abnormalities in attention, repetitive stereotyped behaviors, or narrow interests) 3) M-CAHT-R screening score =3 points; 1) ~3) Either match and 4) Normal vision. Control group inclusion criteria: both match 1) No obvious abnormality in birth history and personal development history: full-term birth, birth weight =2.5kg, no history of hypoxia rescue; No significant abnormalities in previous developmental screening; 2) Negative family history: grandparents, father, mother, and siblings have no ASD, language delay, developmental delay, intellectual disability, ADHD; 3) no core symptoms of ASD in the DSM-5 diagnostic criteria (i.e., abnormalities in attention, repetitive stereotyped behaviors, or narrow interests); 4) M-CAHT-R screening =2 points; 5) Normal vision.
Exclusion criteria
Exclusion criteria: High-risk ASD group: 1) A clear history of craniocerebral trauma, a history of serious physical diseases, and a clear etiological diagnosis of neurodevelopmental disorders; 2) Those who have taken neuropsychiatric drugs in the past six months; 3) Contraindications of magnetic resonance detection. Control group: 1) Clear history of craniocerebral trauma, history of serious physical diseases, epilepsy, and use of neuropsychiatric drugs in the past six months, 2) Contraindications of magnetic resonance detection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| behavioral measures: CARS, ADOS-2,M-CHAT;eye tracking measures: first fixation time, fixation duration, and percentage of fixation time for each area of interest;EEG measures: latency and amplitude of EEG components related to emotional stimuli; | — |
Secondary
| Measure | Time frame |
|---|---|
| developmental and adaptive behavior measures:Griffiths Mental Development Scales or Gesell scale, Adaptive Behavior Assessment System, (ABAS-II); | — |
Countries
China
Contacts
Public ContactBinrang Yang
Shenzhen Children's Hostipal
Outcome results
None listed