Helicobacter pylori infection
Conditions
Interventions
Gold Standard:1) For patients undergoing gastroscopy, the rapid urease test (RUT) of Gastric mucosa tissue, tissue section staining or bacterial culture are positive in any of the three items, and one
The test results of both specimens were negative and were determined to be negative
Note: Routine staining of Gastric mucosa (H&E stain) can usually effectively diagnose HP infection. When the histology of Gastric mucosa in patients shows chronic active inflammation and the routine s
2) UBT (13C or 14C) is the most recommended non-invasive diagnostic method for HP infection in clinical practice. Its results indicate that one of the two specimens tested positive, indicating a posit
3) Monoclonal fecal antigen test will be used as an alternative to UBT, while serological test is mainly used for epidemiological investigation and not as a diagnostic method for current HP infection.
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis meets the diagnostic criteria of western medicine: the clinical manifestations are dyspepsia symptoms such as upper abdominal fullness, upper abdominal pain, acid regurgitation, Heartburn and anorexia, without specificity, and the endoscopic diagnostic criteria refer to the Endoscopic Classification and Grading Standards for Chronic Gastritis (2004 Edition) [17] and the trial treatment opinions. Pathological diagnosis criteria refer to Atrophic gastritis diagnosed in the 2012 Chinese Consensus on Chronic Gastritis [16]; 2. Age: 20-75 years old; 3. Those who have gone to the Digestive Endoscopy Center of Central South Hospital of Wuhan University since 2021. 4. Those who have completed confocal microscopy endoscopy examination.
Exclusion criteria
Exclusion criteria: 1. Patients with concomitant peptic ulcer and severe gastrointestinal bleeding; 2. Patients with concurrent abdominal infection and intestinal obstruction; 3. Patients with severe heart, liver, and kidney dysfunction; 4. Pregnant and lactating women; 5. Allergic constitution or Drug allergy; 6. Those who have recently (within one month) used antibiotics; 7. The patient has Mental disorder and cannot cooperate to complete the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Consistency of confocal endoscopy and clinical diagnostic criteria in diagnosis of Atrophic gastritis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity,SEN;Specificity,SPE;positive predictive value ,PPV;negative predictive value,NPV;The eradication rate of HP infection in Atrophic gastritis patients; | — |
Countries
China
Contacts
Public ContactJing Liu
Zhongnan Hospital of Wuhan University
Outcome results
None listed