Preoperative anxiety
Conditions
Interventions
Propofol group:Failed separation when intravenous injection of 0.05mg/kg of midazolam, than Propofol 2 mg/kg was administered intravenously.
Esketamine group:Failed separation when intravenous injection of 0.05mg/kg of midazolam, than Eskekamine 0.05 mg/kg was administered intravenously.
Sponsors
EYE & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
2 Years to 10 Years
Inclusion criteria
Inclusion criteria: Children aged 2-10 years old; ASA grading I - II; Receiving elective tonsil and/or adenoid surgery under general anesthesia; Parent-child separation failed after intravenous injection of midazolam.
Exclusion criteria
Exclusion criteria: The child is allergic to the experimental medication; Children with neurological and psychiatric disorders; The child is not accompanied by a guardian; Cancellation or postponement of surgery; The guardian refused to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypoxemia (SpO2<92% for more than 10s) during the period from administration to induction of anesthesia.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Is there any physical activity during the period from administration to anesthesia induction;Is there any coughing during the period from administration to induction of anesthesia;Other adverse events during the period from administration to anesthesia induction;Drug onset time;Does the child have resistance during mask pre oxygenation;Heart rate of the child before administration;Oxygen saturation of the child before administration;The heart rate of the child at the onset of drug action;Lowest oxygen saturation during administration to anesthesia induction;Heart rate at the lowest oxygen saturation;The occurrence time of the lowest oxygen saturation;Duration of oxygen saturation less than 92%;Time from administration to induction of anesthesia;Respiratory recovery time after entering the resuscitation room;Extubation time after entering the resuscitation room;Recovery time;Emergence agitation score;Children's Pain Score (FLACC Score) during 24 hours after surgery;Incidence of nausea and vomiting during 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactJie Jia
EYE & ENT Hospital of Fudan University
Outcome results
None listed