gout
Conditions
Interventions
Traditional Chinese Medicine Group:Qifu Huazhuo Formula (250ml/time, twice a day, oral)
Traditional Chinese add Western Medicine Group:Febuxostat (40mg/dose, once daily, oral)+Qifu Huazhuo Formula (250ml/dose, twice daily, oral)
Western Medicine Group:Febuxostat (40mg/dose, once daily, oral)
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria of traditional Chinese and Western medicine for intercritical gout and chronic gouty arthritis; (2) During the screening period, the uric acid level is higher than 420 µ mol/L; (3) Men or women aged 18-65; (4) Sign an informed consent form and be able to adhere to the research visit schedule.
Exclusion criteria
Exclusion criteria: (1) Patients with cardiovascular diseases such as coronary heart disease, heart failure, and arrhythmia; (2) Have a history of allergies to relevant experimental drugs (including experimental drugs, control drugs, etc.); (3) The ALT value during the screening period is greater than 1.5 times the upper limit of the normal value; (4) During the screening period, blood creatinine140/90mmHg), poor blood glucose control (HbA1c>7%), and poor blood lipid control (total cholesterol>5.2 mmol/L, triglycerides>1.7 mmol/L); (11) Patients who are using thioprine or azathioprine; (12) The physician's evaluation and judgment may cause interference with the experimental results; (For example, individuals with clear hematological disorders, malignant tumors, steroid therapy, mental illness, or drug or other substance abuse;)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percent change in serum uric acid from baseline at final visit; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in ultrasound imaging from baseline at final visit;Changes in glomerular filtration rate from baseline at final visit;Number of gout flares during treatment;Patient outcome report scale from baseline at final visit;Scoring of core syndrome information collection and representation of dampness syndrome in traditional Chinese medicine from baseline at final visit; | — |
Countries
China
Contacts
Public ContactZhengdong Shen
Zhuhai Branch of Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed