Obsessive Compulsive Disorder
Conditions
Interventions
Obsessive compulsive disorder:none
Healthy control group:none
Sponsors
the Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patient group inclusion criteria: (1) Subjects were outpatients/inpatients (but subjects participating in the trial did not require hospitalization), and subjects met the DSM-5 diagnostic criteria for obsessive-compulsive disorder as determined by the MINI interview. (2) YBOCS-10 score = 16, or YBOCS-10 score of = 10 on the obsessive-compulsive thinking factor and = 6 on the obsessive-compulsive behavior factor. (3) Age 18-60 years old, regardless of gender. (4) Right-handedness. (5) junior high school education or above, ability to complete informed consent and complete cognitive tests. (6) During the follow-up period, subjects may take medication as prescribed by the outpatient or inpatient physician. Healthy control group inclusion criteria: (1) Subjects were recruited as healthy controls, and it was determined through the MINI interview that subjects did not meet any of the DSM-5 diagnostic criteria for mental disorders. (2) Age 18-60 years, regardless of gender; (3) Right-handedness; (4) Junior high school education or above, with the ability to complete informed consent and complete cognitive tests;
Exclusion criteria
Exclusion criteria: (1) Exclusion of patients with psychotic symptoms. (2) Exclusion of other serious mental illnesses (except generalized anxiety) that meet DSM-5 diagnostic criteria (via the MINI interview), including schizophrenia, schizoaffective disorder, schizophrenia-like disorder, delusional disorder or current psychotic symptoms, post-traumatic stress disorder (current or within the past year), or poor mental status. (3) With organic brain and serious physical illness (e.g., thyroid disease, lupus erythematosus, diabetes, pulmonary, hepatic, and renal impairment, infection, major trauma, etc.) excluding the presence of intracranial implants. (4) Those with serious suicidal ideation or suicide attempts (5) Patients on hormonal medication; (6) clinically significant sensory impairment that cannot be corrected (e.g., hearing impairment that prevents conversation) (7) Pregnant and lactating women (8) Other conditions that, in the opinion of the investigator, exist that make participation in this study inappropriate. Healthy control group exclusion criteria: (1) Patients who currently or previously meet any of the DSM-5 diagnostic criteria for mental disorders (2) Patients with organic brain and serious physical disease (e.g., thyroid disease, lupus erythematosus, diabetes mellitus, pulmonary, hepatic and renal impairment, infection, major trauma, etc.) excluding the presence of intracranial implants; (3) Patients being treated with hormonal drugs. (4) clinically significant sensory impairment that cannot be corrected (e.g., hearing impairment that prevents conversation) (5) Pregnant and lactating women; (6) Other conditions that, in the opinion of the investigator, exist that make participation in this study inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical self-assessment scales;EEG data;MRI;cognitive function; | — |
Countries
China
Contacts
Public ContactYumeng Ju
the Second Xiangya Hospital of Central South University
Outcome results
None listed